Dietary S-Allyl-L-cysteine Reduces Mortality with Decreased Incidence of Stroke and Behavioral Changes in Stroke-Prone Spontaneously Hypertensive Rats

Stroke-Prone Spontaneously Hypertensive Rats

Background and Purpose We examined metabolic and functional changes when forebrain ischemia was induced in strokeprone spontaneously hypertensive rats by bilateral carotid artery occlusion. In addition, the protective effect of clentiazem was evaluated in this model. Methods Rats were anesthetized with urethane. Cerebral blood flow was measured with a laser Doppler fkrwmeter. Cerebral high-ener...

Postnatal undernutrition accelerates incidence of stroke in stroke-prone spontaneously hypertensive rats.

The effect of infantile nutritional levels on the development of hypertension and incidence of stroke was investigated in stroke-prone spontaneously hypertensive rats (SHRSP). Caloric intake was varied during the suckling period by manipulating litter size immediately after birth; however, all animals had free access to food after weaning. Animals reared in large litters of 15 (LL group) weighe...

Cerebral plasminogen activator activity in spontaneously hypertensive stroke-prone rats.

BACKGROUND AND PURPOSE In the spontaneously hypertensive stroke-prone rat, it is unclear whether plasminogen activator plays a role in the development of stroke. The present study was undertaken to investigate brain levels of plasminogen activator activity in spontaneously hypertensive stroke-prone rats and Wistar-Kyoto rats. METHODS Plasminogen activator was purified from the brains of rats ...

Platelet survival studies in stroke-prone spontaneously hypertensive rats (SHRSP).

Platelet survival was studied by using 51Cr-labeled platelets in stroke-prone spontaneously hypertensive rats (SHRSP), stroke-resistant SHR (SHRSR) and normotensive control rats of the Wistar-Kyoto (WK) strain. Relatively young animals of the same age prior to the development of cerebrovascular lesions (cerebral infarction and/or hemorrhage) were used. Platelet half-life time in SHRSP was sligh...

Effect of dietary taurine on lipid metabolism in normcholesterolemic and hypercholesterolemic stroke-prone spontaneously hypertensive rats.